在胆酸生物合成过程中3α,7α,12α,24-四羟基-5β-胆甾烷-26-酸的非立体选择性形成。
Non-stereoselective formation of 3 alpha,7 alpha,12 alpha,24-tetrahydroxy-5 beta-cholestan-26-oic acid during cholic acid biosynthesis.
作者信息
Kobayashi N, Hagiwara C, Morisaki M, Yuri M, Oya I, Fujimoto Y
机构信息
Kyoritsu College of Pharmacy, Tokyo, Japan.
出版信息
Chem Pharm Bull (Tokyo). 1994 May;42(5):1028-35. doi: 10.1248/cpb.42.1028.
Incubation of (25RS)-, (25R)- and (25S)-3 alpha,7 alpha,12 alpha-trihydroxy-5 beta-cholestan-26-oic acid (THCA, 6, 6a, 6b) and (24E)-3 alpha,7 alpha,12 alpha-trihydroxy-5 beta-cholest-24-en-26-oic acid (7) with rat liver mitochondria gave all four stereoisomers (9a,9b,9c,9d) of 3 alpha,7 alpha,12 alpha,24-Tetrahydroxy-5 beta-cholestan-26-oic acid (TeHCA). The corresponding 27-nor analogs (10,11) were also converted non-stereoselectively to a 1:1 mixture of the epimeric 24-hydroxy compounds (12).
将(25RS)-、(25R)-和(25S)-3α,7α,12α-三羟基-5β-胆甾烷-26-酸（THCA，6、6a、6b）以及(24E)-3α,7α,12α-三羟基-5β-胆甾-24-烯-26-酸（7）与大鼠肝脏线粒体一起温育，得到了3α,7α,12α,24-四羟基-5β-胆甾烷-26-酸（TeHCA）的所有四种立体异构体（9a、9b、9c、9d）。相应的27-降（nor）类似物（10、11）也非立体选择性地转化为差向异构的24-羟基化合物（12）的1:1混合物。
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