Nowicki P T, Nankervis C A
Department of Pediatrics, Ohio State University, Columbus.
Clin Perinatol. 1994 Jun;21(2):219-34.
Early descriptions of necrotizing enterocolitis (NEC) proposed gut ischemia as a primary factor in pathogenesis. Subsequent laboratory and clinical investigations have failed to support these theories, relegating most to positions of historical significance. Presently, the role of the circulation in the pathogenesis of NEC is unclear; however, several lines of ongoing investigation have begun to provide novel insight into the means by which circulatory aberration may initiate or contribute to the development of bowel necrosis.
早期对坏死性小肠结肠炎（NEC）的描述提出肠道缺血是发病机制中的主要因素。随后的实验室和临床研究未能支持这些理论，多数已沦为具有历史意义的观点。目前，循环系统在NEC发病机制中的作用尚不清楚；然而，正在进行的几项研究已开始为循环系统异常可能引发或促成肠坏死发展的方式提供新的见解。
