Marek J, Motlik K
Virchows Arch B Cell Pathol. 1975;18(2):145-56. doi: 10.1007/BF02889243.
The main ultrastructural feature of human adrenal cortices following administration of aminoglutethimide (Elipten CIBA), a steroid biosynthesis blocking agent, is a striking intracellular accumulation of lipids, also seen in the light microscopy. The lipids accumulate in the adrenocortical cells but are also stored in the cytoplasm of pericapillary histiocytes. The lipids are present in the adrenocortical cells mostly as rounded liposomes of variable size, whereas those in the histiocytes usually show up as an amorphous debris with abundant myelin figures and cholesterol crystals. In some areas of the adrenal cortex activated histiocytes changing into lipophages may become the prevalent cell. They also take the place of destroyed adrenocortical cells and can form compact cell aggregates of variable size or even columnar strands between neighbouring capillaries, thus resembling columns of adrenocortical cells. In some of the adrenocortical cells focal cytoplasmic degradation, turning into coagulation necrosis, was observed. In others initial cytolysis was found. In contrast with earlier findings in experimental animals, mitochondrial changes in humans were not a prominent feature. The only changes occasionally observed were a focal disappearance of the vesicular cristae and a concomitant fibrillary loosening of the mitochondrial matrix.
给予甾体生物合成阻断剂氨鲁米特（伊立替康，西巴）后，人肾上腺皮质的主要超微结构特征是细胞内脂质显著蓄积，这在光学显微镜下也可见。脂质在肾上腺皮质细胞中蓄积，但也储存在毛细血管周围组织细胞的细胞质中。脂质在肾上腺皮质细胞中大多以大小不一的圆形脂质体形式存在，而在组织细胞中的脂质通常表现为具有丰富髓鞘样结构和胆固醇结晶的无定形碎片。在肾上腺皮质的某些区域，活化的组织细胞转变为噬脂细胞可能成为优势细胞。它们还取代被破坏的肾上腺皮质细胞，可形成大小不一的紧密细胞聚集体，甚至在相邻毛细血管之间形成柱状条索，从而类似肾上腺皮质细胞柱。在一些肾上腺皮质细胞中观察到局灶性细胞质降解，进而发展为凝固性坏死。在其他细胞中则发现了初始的细胞溶解。与在实验动物中的早期发现不同，人类线粒体的变化并非显著特征。偶尔观察到的唯一变化是泡状嵴的局灶性消失以及线粒体基质随之出现的纤维性疏松。
