患有外阴和前庭乳头瘤病的年轻女性的生殖器人乳头瘤病毒感染

Genital human papillomavirus infections in young women with vulvar and vestibular papillomatosis.

作者信息

Pao C C, Hor J J, Fu Y L

机构信息

Department of Biochemistry, Chang Gung Medical College, KweiShan, Tao Yuan, Taiwan.

出版信息

Eur J Clin Microbiol Infect Dis. 1994 May;13(5):433-6. doi: 10.1007/BF01972005.

DOI:10.1007/BF01972005

PMID:8070461

Abstract

Possible involvement of human papillomaviruses (HPV) in the development of vulvar and vestibular papillomatosis was investigated by using PCR to determine whether HPV DNA was present in lesions. Fourteen of 272 (5.1%) young women studied were found on gross and histological examination to have vulvar or vestibular papillomatosis. HPV DNA sequences were detected in cervicovaginal lavage specimens of 2 of 14 (14.3%) papillomatosis patients and 1 of 17 (5.9%) matched individuals in the control group without lesions. The difference in HPV prevalence between these two groups was not statistically significant (x2 = 0.51, p > 0.2). Furthermore, none of the 14 vulvar or vestibular papillomatosis biopsy tissues contained HPV DNA. The results suggest that vulvar and vestibular papillomatosis has an etiology other than HPV infection.

摘要

通过聚合酶链反应（PCR）检测病变中是否存在人乳头瘤病毒（HPV）DNA，来研究HPV是否可能参与外阴和前庭乳头瘤病的发展。在接受研究的272名年轻女性中，经大体和组织学检查发现，有14名（5.1%）患有外阴或前庭乳头瘤病。在14名乳头瘤病患者中的2名（14.3%）以及17名无病变的匹配对照组个体中的1名（5.9%）的宫颈阴道灌洗标本中检测到了HPV DNA序列。这两组之间HPV感染率的差异无统计学意义（x2 = 0.51，p > 0.2）。此外，14例外阴或前庭乳头瘤病活检组织中均未检测到HPV DNA。结果表明，外阴和前庭乳头瘤病的病因并非HPV感染。