Klemetsdal B, Straume B, Giverhaug T, Aarbakke J
Department of Pharmacology, University of Tromsø, Norway.
Eur J Clin Pharmacol. 1994;46(3):231-5. doi: 10.1007/BF00192554.
Catechol-O-methyltransferase (COMT) catalyzes the O-methylation of catechol hormones, neurotransmitters and certain drugs. It is subject to genetic polymorphism and ethnic differences. High red blood cell (RBC) COMT activity has been correlated with a poor response to levodopa treatment in Parkinson's disease. RBC COMT was determined in a Norwegian population (n = 213) of whom 115 were Saami (Laaps). The Saami had 16.5% lower RBC COMT activity compared to a non-Saami population sample from the northern part of Norway (n = 50), 13.9 vs. 16.4 units/ml RBC (U) (P = 0.04). This is the first report of any population with lower RBC COMT activity than a Caucasian population. A wide range of RBC COMT activities was found in the entire population examined (1.3-38.3 U).
儿茶酚-O-甲基转移酶（COMT）催化儿茶酚胺类激素、神经递质及某些药物的O-甲基化反应。该酶存在基因多态性和种族差异。在帕金森病患者中，红细胞（RBC）COMT活性高与左旋多巴治疗反应差相关。对挪威人群（n = 213）进行了红细胞COMT测定，其中115人为萨米人（拉普人）。与来自挪威北部的非萨米人群样本（n = 50）相比，萨米人的红细胞COMT活性低16.5%，分别为13.9和16.4单位/毫升红细胞（U）（P = 0.04）。这是首次报道红细胞COMT活性低于高加索人群的任何群体。在所检测的整个人群中发现红细胞COMT活性范围很广（1.3 - 38.3 U）。
