人类血红蛋白氧平衡曲线的S形及P50
Sigmoid shape of the oxygen equilibrium curve and the P50 of human hemoglobin.
作者信息
Kobayashi M, Satoh G, Ishigaki K
机构信息
Department of Biology, Faculty of Science, Niigata University, Japan.
出版信息
Experientia. 1994 Aug 15;50(8):705-7. doi: 10.1007/BF01919366.
The fractional saturation of hemoglobin with oxygen was plotted against P/P50 and the slope of the abscissa at 1 was calculated for 38 OEC data sets of human Hb A. There was a linear correlation between the slope and the Hill coefficient (nmax), and the slope was about one-fourth that of nmax. This implies that the slope of the abscissa at 1 of Y vs P/P50 plot can provide information about the magnitude of cooperativity in hemoglobin oxygen binding.
针对人血红蛋白A的38个氧增强对比度（OEC）数据集，绘制了血红蛋白氧分数饱和度与P/P50的关系图，并计算了横坐标在1处的斜率。该斜率与希尔系数（nmax）之间存在线性相关性，且该斜率约为nmax的四分之一。这意味着Y对P/P50作图中横坐标在1处的斜率能够提供有关血红蛋白氧结合协同性大小的信息。
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