清醒小牛体内一氧化氮相关的胰腺内分泌对高血糖的反应

Nitric oxide-related pancreatic endocrine responses to hyperglycaemia in the conscious calf.

作者信息

Edwards A V, Ghatei M A, Bloom S R

机构信息

Physiological Laboratory, University of Cambridge, UK.

出版信息

Experientia. 1994 Aug 15;50(8):725-6. doi: 10.1007/BF01919371.

DOI:10.1007/BF01919371

PMID:8070533

Abstract

Mean plasma insulin concentration was reduced and mean plasma glucose concentration increased following the administration of N-nitro-L-arginine methyl ester (L-NAME; 100 mumol kg-1 i.a.) in conscious calves given continuous infusions of exogenous glucose (30-60 mumol min-1 kg-1 i.v.). It is concluded that the rise in plasma insulin concentration which occurs in these animals in response to glucose is mediated, at least in part, by a nitric oxide-related factor (NOx).

摘要

在持续静脉输注外源性葡萄糖（30 - 60 μmol·min⁻¹·kg⁻¹）的清醒犊牛中，给予N - 硝基 - L - 精氨酸甲酯（L - NAME；100 μmol·kg⁻¹，腹腔注射）后，血浆胰岛素平均浓度降低，血浆葡萄糖平均浓度升高。得出的结论是，这些动物对葡萄糖产生反应时血浆胰岛素浓度的升高至少部分是由一氧化氮相关因子（NOx）介导的。