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Alpha-dystroglycan deficiency correlates with elevated serum creatine kinase and decreased muscle contraction tension in golden retriever muscular dystrophy.

作者信息

Ervasti J M, Roberds S L, Anderson R D, Sharp N J, Kornegay J N, Campbell K P

机构信息

Department of Physiology, University of Wisconsin Medical School, Madison 53706.

出版信息

FEBS Lett. 1994 Aug 22;350(2-3):173-6. doi: 10.1016/0014-5793(94)00748-9.

DOI:10.1016/0014-5793(94)00748-9
PMID:8070559
Abstract

The dystrophin-glycoprotein complex was examined in dystrophin-deficient dogs with golden retriever muscular dystrophy (GRMD) using immunoblot and immunofluorescence analysis. The dystrophin-associated proteins were substantially reduced in muscle from dogs with GRMD. Interestingly, regression analysis revealed a strong correlation between the amount of alpha-dystroglycan and serum creatine kinase levels and the contraction tension measured for a given peroneus longus muscle.

摘要

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