Kula K, Salata I M, Słowikowska-Hilczer J
Pracowni Andrologii Klinicznej Instytutu Endokrynologii AM, Lodzi.
Ginekol Pol. 1994 Feb;65(2):58-62.
During 14 subsequent days male Wistar rats received subcutaneously 50 micrograms of EB and different doses of tamoxifen intratesticularly. Action of EB was examined by comparison with the group, which received the solvent for EB only. EB caused the reduction in the mean testis weight, degenerative changes of germinal cells and decrease of blood testosterone level to undetectable values. Tamoxifen did not prevent these changes, but revealed a positive influence on the mean numbers of spermatogonia, spermatocytes and spermatids, including spermatozoa. It indicates that tamoxifen may stimulate the whole spermatogenesis in spite of the inhibition of testosterone production.
在随后的14天里，雄性Wistar大鼠皮下注射50微克己烯雌酚（EB），并向睾丸内注射不同剂量的他莫昔芬。通过与仅接受EB溶剂的组进行比较，来研究EB的作用。EB导致平均睾丸重量减轻、生殖细胞发生退行性变化以及血液睾酮水平降至无法检测的值。他莫昔芬并未阻止这些变化，但对精原细胞、精母细胞和精子细胞（包括精子）的平均数量显示出积极影响。这表明，尽管睾酮生成受到抑制，但他莫昔芬可能会刺激整个精子发生过程。
