Segal N, Barak Y
Pediatrics Dept. A, Kaplan Hospital, Rehovot.
Harefuah. 1994 Apr 15;126(8):438-40, 491-2.
Hemangioma, the most common tumor of infancy, is usually harmless. It frequently appears soon after birth, proliferates for 8-18 months, and then slowly regresses over the next 5-8 years, leaving the skin normal or only slightly blemished. However, hemangiomas sometimes cause devastating tissue damage and may be associated with thrombocytopenia and life-threatening hazards. About a third of these cases respond to corticosteroid therapy, but often with rapid rebound following its discontinuation. Successful treatment of large and life-threatening hemangiomas with interferon alpha-2a has recently been reported. We found it effective in a 3.5-month-old male with a large symptomatic hemangioma. After 6 months of daily interferon alpha-2a (Referon, Hoffman-LaRoche), 3 million units/m2/day, all symptoms disappeared and the lesion was halved in size. There were no significant side-effects. This treatment is effective and safe and should be considered in infants with large, symptomatic hemangiomas.
血管瘤是婴儿期最常见的肿瘤，通常无害。它常在出生后不久出现，增殖8 - 18个月，然后在接下来的5 - 8年里缓慢消退，使皮肤保持正常或仅有轻微瑕疵。然而，血管瘤有时会导致严重的组织损伤，可能与血小板减少症及危及生命的风险相关。约三分之一的此类病例对皮质类固醇治疗有反应，但停药后常迅速复发。最近有报道称，用α-2a干扰素成功治疗了大型且危及生命的血管瘤。我们发现它对一名患有大型有症状血管瘤的3.5个月大男性有效。在每日注射α-2a干扰素（罗扰素，霍夫曼-罗氏公司）300万单位/平方米，持续6个月后，所有症状消失，病变大小减半。没有明显的副作用。这种治疗有效且安全，对于患有大型有症状血管瘤的婴儿应予以考虑。
