Bardakjian B L, Vigmond E J
Institute of Biomedical Engineering, University of Toronto, Ontario, Canada.
IEEE Trans Biomed Eng. 1994 May;41(5):432-9. doi: 10.1109/10.293217.
Extracellular electric fields have been proposed as a mechanism for electrical coupling between excitable cells. This study deals with the extracellular potential produced by an isolated excitable spherical cell due to a traveling depolarization wave on the cell's surface. Both uniform and nonuniform propagation velocity profiles are considered. Using boundary element methods, the extracellular potential was computed. The polarity of the extracellular potential was found to be space-dependent. The peak extracellular potential increased when a) the propagation velocity decreased, b) the rise time of the depolarization decreased, and c) the extracellular resistivity increased.
细胞外电场已被提出作为可兴奋细胞间电耦合的一种机制。本研究探讨了由于细胞表面传播的去极化波，孤立的可兴奋球形细胞产生的细胞外电位。考虑了均匀和非均匀传播速度分布。使用边界元方法计算细胞外电位。发现细胞外电位的极性与空间有关。当a）传播速度降低，b）去极化的上升时间减少，以及c）细胞外电阻率增加时，细胞外电位峰值增加。
