Lindbohm M L
Institute of Occupational Health, Helsinki, Finland.
IARC Sci Publ. 1993(127):163-9.
Styrene has been shown to cross the placenta. Studies in animals suggest that styrene and styrene oxide have embryotoxic or fetotoxic effects early in pregnancy, but there is no evidence with regard to teratogenicity. This paper is a review of epidemiological investigations on the effects of occupational exposure to styrene on the reproductive health of women. The results of these studies are contradictory. Some early reports suggested that exposure to styrene induces menstrual disturbances, spontaneous abortions and congenital malformations. In more recent studies, no risk was observed among workers exposed to styrene in the reinforced-plastics industry. An excess of spontaneous abortions was, however, indicated by one investigation in women whose work included the processing of polystyrene. Two studies also suggested associations between exposure to styrene and low birth weight and reduced fertility. Although some epidemiological studies suggest that exposure to styrene involves reproductive hazards, the validity of most of these studies is weakened by methodological shortcomings. The available evidence cannot be used to draw any firm conclusions.
已证实苯乙烯可穿过胎盘。动物研究表明，苯乙烯和环氧苯乙烯在妊娠早期具有胚胎毒性或胎儿毒性，但尚无致畸性方面的证据。本文是关于职业接触苯乙烯对女性生殖健康影响的流行病学调查综述。这些研究结果相互矛盾。一些早期报告表明，接触苯乙烯会导致月经紊乱、自然流产和先天性畸形。在最近的研究中，未观察到增强塑料行业接触苯乙烯的工人存在风险。然而，一项针对从事聚苯乙烯加工工作的女性的调查表明自然流产过多。两项研究还表明接触苯乙烯与低出生体重和生育力降低之间存在关联。尽管一些流行病学研究表明接触苯乙烯存在生殖危害，但这些研究大多因方法上的缺陷而使其有效性受到削弱。现有证据无法得出任何确凿结论。
