van Wachem P B, van Luyn M J, Olde Damink L H, Dijkstra P J, Feijen J, Nieuwenhuis P
Department of Cell Biology and Electron Microscopy, University of Groningen, The Netherlands.
Int J Artif Organs. 1994 Apr;17(4):230-9.
In future, the function of collagen-based biomaterials as temporary scaffolds for the generation of new tissue may be emphasized. In this study the function of dermal sheep collagen (DSC) crosslinked with carbodiimide (ENDSC) as repair material for abdominal wall defects in rats was compared with that of commercial hexamethylenediisocyanate-crosslinked HDSC. The results indicate that early after implantation both ENDSC and HDSC functioned well as a matrix for cellular ingrowth. However during further implantation HDSC soon degraded resulting in herniations, while ENDSC showed a delay in the degradation time of at least 20 weeks. ENDSC thereby enabled collagen new-formation and functioned as a guidance for muscle overgrowth. These results are very promising concerning the problem of the ongoing foreign body reaction with continuing risk of implant rejection observed in clinical practice with non-degradable materials.
未来，基于胶原蛋白的生物材料作为生成新组织的临时支架的功能可能会得到重视。在本研究中，将用碳二亚胺交联的真皮羊胶原蛋白（ENDSC）作为大鼠腹壁缺损修复材料的功能与市售六亚甲基二异氰酸酯交联的HDSC的功能进行了比较。结果表明，植入早期，ENDSC和HDSC均能很好地作为细胞向内生长的基质。然而，在进一步植入过程中，HDSC很快降解，导致疝形成，而ENDSC的降解时间延迟至少20周。ENDSC因此能够促进胶原蛋白的新形成，并作为肌肉过度生长的引导。这些结果对于临床实践中使用不可降解材料时持续存在的异物反应和植入排斥持续风险问题而言非常有前景。
