Hyde C, Johnson T, Owen D, Quibell M, Sheppard R C
MRC Laboratory of Molecular Biology, Cambridge, UK.
Int J Pept Protein Res. 1994 May;43(5):431-40.
Case studies of the solid-phase synthesis of some 'difficult sequences' using continuous-flow Fmoc-polyamide techniques are presented. Solvent change and peptide side chain and backbone modification procedures recently found to reduce association effects are applied, and the results compared to syntheses under standard conditions.
本文介绍了使用连续流动Fmoc-聚酰胺技术固相合成一些“困难序列”的案例研究。应用了最近发现可减少缔合效应的溶剂变化、肽侧链和主链修饰程序，并将结果与标准条件下的合成结果进行了比较。
