Baum H P, Hog M
Hautklinik, Universität des Saarlandes, Homburg/Saar.
Hautarzt. 1994 Jun;45(6):406-8. doi: 10.1007/s001050050093.
It is rare for solitary basal cell cancer not to be associated with the naevoid basal cell carcinoma syndrome (NBCCS), xeroderma pigmentosum, an organoid nevus or X-ray therapy in children (to date 86 cases have been documented in the literature. Aetiologically, the tumours might be a forme fruste of the NBCCS or they might follow a somatic point mutation of keratinocytes. Up to now, data on the repair mechanism following UV-induced DNA damage are not available in these patients. We report on a 10-year-old boy with a solitary nodular basal cell cancer in the right malar region. Neither the patient's history nor the clinical findings suggested a genetic disposition to development of the tumour.
孤立性基底细胞癌不伴有痣样基底细胞癌综合征（NBCCS）、着色性干皮病、器官样痣或儿童期接受过X线治疗的情况较为罕见（迄今为止，文献中已记载86例）。从病因学角度来看，这些肿瘤可能是NBCCS的不完全型，或者可能是角质形成细胞发生体细胞点突变所致。到目前为止，这些患者紫外线诱导的DNA损伤后修复机制的数据尚不可得。我们报告了一名10岁男孩，其右侧颊部有一个孤立性结节性基底细胞癌。患者的病史和临床检查结果均未提示该肿瘤有遗传易感性。
