与长期苯妥英治疗相关的足跟垫增厚。

Thickening of the heel-pad associated with long-term Dilantin therapy.

作者信息

Kattan K R

出版信息

Am J Roentgenol Radium Ther Nucl Med. 1975 May;124(1):52-6. doi: 10.2214/ajr.124.1.52.

DOI:10.2214/ajr.124.1.52

Abstract

Thickening of the heel-pad is added to the list of side effects of Dilantin medication. Any measurement above 20 mm. in a white patient was considered abnormal. Only 1 of 43 controls measured above this value, while in patients receiving Dilantin the percentage of patients manifesting abnormally thickened hell-pads increased steadily with length of treatment; after 10 years 7 out of 12 patients showed this change. Dilantin medication should be included in the differential diagnosis of heel-pad thickening.

摘要

足跟垫增厚被列入苯妥英药物的副作用清单。白人患者足跟垫厚度超过20毫米被视为异常。43名对照组中只有1人测量值高于此数值，而接受苯妥英治疗的患者中，足跟垫异常增厚的患者比例随治疗时间稳步上升；10年后，12名患者中有7人出现了这种变化。苯妥英药物应列入足跟垫增厚的鉴别诊断之中。