Haydon P G, Zoran M J
Department of Zoology and Genetics, Iowa State University, Ames 50011.
J Neurobiol. 1994 Jun;25(6):694-706. doi: 10.1002/neu.480250609.
Major advances are occurring in our understanding of the events leading to synapse formation. Contact between the growth cone and target tissue leads to intercellular signaling which controls both pre- and postsynaptic development of the synapse. The identity of retrograde signals that regulate presynaptic development are beginning to emerge, and the signal transduction cascades that are activated presynaptically are being characterized. Recent studies have shown that both the resting calcium level and activation of presynaptic protein kinase A are critical in the development of the presynaptic terminal. An understanding of these regulatory mechanisms is beginning to provide insight into the molecular control of synaptic specificity.
在我们对导致突触形成的事件的理解方面正在取得重大进展。生长锥与靶组织之间的接触会引发细胞间信号传导，该信号传导控制着突触的突触前和突触后发育。调节突触前发育的逆行信号的身份开始显现，并且正在对突触前激活的信号转导级联进行表征。最近的研究表明，静息钙水平和突触前蛋白激酶A的激活在突触前终末的发育中都至关重要。对这些调节机制的理解开始为突触特异性的分子控制提供见解。
