含福辛普利钠的层状液晶

A lamellar liquid crystal with fosinopril sodium.

作者信息

Friberg S E, Moaddel T, Morris K R, Abramowitz R, Amsberry K L

机构信息

Center for Advanced Materials Processing, Clarkson University, Potsdam, NY 13699-5814.

出版信息

J Pharm Sci. 1994 May;83(5):677-9. doi: 10.1002/jps.2600830517.

DOI:10.1002/jps.2600830517

PMID:8071820

Abstract

The location and conformation of fosinopril sodium (FS) in a lamellar liquid crystal of water, sodium dodecyl sulfate, and decanol was studied by low-angle X-ray diffraction. The result showed the FS molecule to be located within the amphiphilic part of the liquid crystalline structure with the polar parts anchored at the water/polar part interface. An area per molecule in the range of 95-100 A2 showed not only the polar groups but also the benzene ring to be located at this interface.

摘要

通过低角度X射线衍射研究了福辛普利钠（FS）在水、十二烷基硫酸钠和癸醇的层状液晶中的位置和构象。结果表明，FS分子位于液晶结构的两亲部分内，其极性部分锚定在水/极性部分界面处。每个分子的面积在95 - 100 Å²范围内，这表明不仅极性基团而且苯环都位于该界面处。