Krawczyński M R, Latos-Bieleńska A, Pecold K
Zakładu Genetyki Klinicznej, Instytutu Pediatrii AM, Poznaniu.
Klin Oczna. 1993 Nov-Dec;95(11-12):407-11.
The modern view for the mechanisms of retinoblastoma origination, based on the tumor suppressor genes theory, has been described in this work. The structure and function of the retinoblastoma gene and its protein product, with reference to the cell cycle, has been presented. On the ground of this data, possibilities of genetic molecular diagnostics and principles of competent genetic counselling have been described.
