Tomasiewicz K, Modrzewska R, Lyczak A, Rzeszowska G
Katedra i Klinika Chorób Zakaźnych AM, Lublinie.
Przegl Epidemiol. 1994;48(1-2):11-5.
Health care workers are the group at high hepatitis B virus (HBV) infection risk. Groups of physicians and nurses working in hospitals of Lublin have been vaccinated since 1989. The aim of this work was to assess the level of anti-HBs in different years after the basic course of vaccination. We have examined 166 persons, aged from 18 to 65 years, vaccinated with a yeast recombinant hepatitis B vaccine Engerix B (Smith Kline Biologicals). They completed the full cycle of vaccination according to the pattern of 0, 1, 6 months. Within the group of people who had got the third dose one year ago we found 100% of women and 88% of men with a protective level of anti-HBs (> or = 10 IU/l). Four years after the final inoculation differences between female and male population were even more significant: 93% of man had a protective level of anti-HBs. We have also found that humoral response was higher in the group of younger vaccinees (18-40 years). We propose that timing of booster vaccination should be scheduled on the basis of anti-HBs level. It seems to be necessary to control the level of anti-HBs at least 3 years after the last dose of vaccination.
医护人员是感染乙肝病毒（HBV）风险较高的群体。自1989年以来，在卢布林医院工作的医生和护士群体已接种疫苗。这项工作的目的是评估基础疫苗接种疗程后不同年份的抗-HBs水平。我们检查了166名年龄在18至65岁之间、接种了酵母重组乙肝疫苗安在时（史克必成生物制品公司）的人员。他们按照0、1、6个月的接种程序完成了整个接种周期。在一年前接种第三剂疫苗的人群中，我们发现100%的女性和88%的男性抗-HBs水平达到保护水平（≥10 IU/l）。最后一剂接种四年后，男性和女性人群之间的差异更为显著：93%的男性抗-HBs水平达到保护水平。我们还发现，较年轻的接种者（18至40岁）群体的体液反应更高。我们建议应根据抗-HBs水平安排加强疫苗接种的时间。在最后一剂疫苗接种后至少3年检测抗-HBs水平似乎是必要的。
