Sigola L B, Mufunda J, Adewuyi J O, Keogh E
Department of Physiology, University of Zimbabwe, Mount Pleasant, Harare.
Thromb Res. 1994 Jul 1;75(1):73-9. doi: 10.1016/0049-3848(94)90141-4.
Studies in Southern Africa have shown that whites have significantly greater morbidity and mortality from coronary heart disease than blacks. This study investigated the distribution of some haemostatic variables known or suspected to be correlated with greater risk for coronary heart disease in healthy black and white Zimbabwean men. Factor VII, antithrombin III, leukocyte and platelet counts were measured in 56 blacks and 29 whites aged between 20 and 50 years. We found significantly greater factor VII and leukocyte counts in the whites compared to the blacks. The other variables measured were similar in the two ethnic groups. These results suggest that the greater prevalence of coronary heart disease in whites is consistent with high levels of factor VII and white blood cell counts previously identified as risk factors for this condition.
在非洲南部开展的研究表明，白人患冠心病的发病率和死亡率显著高于黑人。本研究调查了一些已知或疑似与冠心病风险增加相关的止血变量在健康的津巴布韦黑人和白人男性中的分布情况。对56名年龄在20至50岁之间的黑人和29名白人测量了凝血因子VII、抗凝血酶III、白细胞和血小板计数。我们发现，与黑人相比，白人的凝血因子VII和白细胞计数显著更高。测量的其他变量在这两个种族群体中相似。这些结果表明，白人中冠心病患病率较高与先前确定为该疾病风险因素的凝血因子VII和白细胞高水平相一致。
