Polzik E V, Katsnel'son B A, Iakusheva M I, Lezhnin V L, Kazantsev V S
Vopr Onkol. 1993;39(1-3):32-9.
Fifty-eight lung cancer and 71 gastric cancer patients were matched with corresponding healthy controls versus such risk factors as age, sex, nationality, tobacco smoking, alcohol drinking and occupation. HLA-antigens and dermatoglyphic patterns were used as genetic markers. Multivariate analysis employed mathematical procedures of pattern recognition. The results using HLA-antigen technique were not satisfactory. On the contrary, lung cancer studies based on 16 most informative dermatoglyphic parameters yielded reliable decision rules which proved 100% effective in control group and 83.3% effective in cancer patients. In gastric cancer studies, the best results (87.5% of correctly recognized patterns in both groups) were obtained, when 20 parameters were used. Correlations between pattern types and cancer of the lung and stomach have been identified. It is suggested that complete dermatoglyphic picture may be used as a marker of genetic predisposition to oncological disease.
58例肺癌患者和71例胃癌患者与相应的健康对照者在年龄、性别、国籍、吸烟、饮酒和职业等风险因素方面进行了匹配。将HLA抗原和皮纹模式用作遗传标记。多变量分析采用模式识别的数学方法。使用HLA抗原技术的结果并不理想。相反，基于16个最具信息量的皮纹参数进行的肺癌研究得出了可靠的决策规则，这些规则在对照组中证明100%有效，在癌症患者中83.3%有效。在胃癌研究中，当使用20个参数时，获得了最佳结果（两组中正确识别模式的比例均为87.5%）。已经确定了模式类型与肺癌和胃癌之间的相关性。有人提出，完整的皮纹图谱可作为肿瘤疾病遗传易感性的标志物。
