Konenkov V I, Arshba G A, Korotkova I I, Prokof'ev V F, Egorov D N, Vardosanidze K V
Vopr Onkol. 1997;43(3):269-72.
An immunogenetic examination of 86 cases of stomach cancer established a correlation between predisposition and resistance, on the one hand, and the distribution of allele sets of HLA-genes (classes I and II), on the other. The relationship was found to vary according to sex and age. The most significant relationships with respect to predisposition were identified for HLA-B51 (RR = 19.82) alleles and allele combinations of HLA-DRI-DR7 (RR = 25.52) and HLA-A9-DRI (RR = 33.67). High relative risk of stomach cancer was attributed to the absence of relevant alleles in 91 patients included into the group of comparison. Also, combinations of allele sets were identified in healthy subjects which never occur in stomach cancer patients. The results provide a substantiation for developing an automated system of interpreting HLA-typing data which are instrumental in evaluating the patient's predisposition, resistance and prognosis.
对86例胃癌患者进行的免疫遗传学检查发现，一方面，易感性和抵抗力与另一方面HLA基因（I类和II类）等位基因组合的分布之间存在相关性。这种关系因性别和年龄而异。就易感性而言，发现与HLA - B51（相对危险度RR = 19.82）等位基因以及HLA - DRI - DR7（RR = 25.52）和HLA - A9 - DRI（RR = 33.67）的等位基因组合关系最为显著。在纳入比较组的91名患者中，胃癌的高相对危险度归因于缺乏相关等位基因。此外，在健康受试者中还发现了胃癌患者中从未出现过的等位基因组合。这些结果为开发一个自动解释HLA分型数据的系统提供了依据，该系统有助于评估患者的易感性、抵抗力和预后。
