乙烯-乙烯醇共聚物（EVAL）混合物的特性
Characteristics of ethylene vinyl alcohol copolymer (EVAL) mixtures.
作者信息
Yamashita K, Taki W, Iwata H, Nakahara I, Nishi S, Sadato A, Matsumoto K, Kikuchi H
机构信息
Department of Neurosurgery, Faculty of Medicine, Kyoto University, Japan.
出版信息
AJNR Am J Neuroradiol. 1994 Jun;15(6):1103-5.
PURPOSE
To determine physical characteristics of mixtures of ethylene vinyl alcohol copolymer (EVAL) and metrizamide dissolved in dimethyl sulfoxide, liquid materials developed for embolization of arteriovenous malformations.
METHODS
EVAL and dimethyl sulfoxide were mixed in various proportions and sterilized. The viscosity and density of each mixture was measured. Precipitation times were determined by dropping the mixtures into saline or human blood. The mixtures were filtered and the filtrates weighed.
RESULTS
Densities and viscosities of the various mixtures differed significantly, proportionally to the concentration of EVAL. Precipitation times also differed significantly, in inverse proportion to the concentration of EVAL. Temperature and aqueous solution did not affect precipitation times significantly. The weight of the filtrate significantly increased with time but was constant for each precipitation time. Temperature significantly affected filtrate weight; aqueous solution did not.
CONCLUSIONS
Because of their different physical properties, the various EVAL mixtures are suited to embolizing different types of arteriovenous malformations.
目的
确定乙烯-乙烯醇共聚物（EVAL）与甲泛葡胺溶解于二甲基亚砜中的混合物的物理特性，这些液体材料用于动静脉畸形的栓塞治疗。
方法
将EVAL与二甲基亚砜按不同比例混合并灭菌。测量每种混合物的粘度和密度。通过将混合物滴入盐水或人血中来确定沉淀时间。对混合物进行过滤并对滤液称重。
结果
各种混合物的密度和粘度差异显著，与EVAL的浓度成比例。沉淀时间也有显著差异，与EVAL的浓度成反比。温度和水溶液对沉淀时间没有显著影响。滤液的重量随时间显著增加，但每个沉淀时间的重量是恒定的。温度对滤液重量有显著影响；水溶液则没有。
结论
由于其不同的物理性质，各种EVAL混合物适合栓塞不同类型的动静脉畸形。
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