口服17-β-雌二醇对既往妊娠期间患有肝内胆汁淤积症（肝内胆汁淤积性肝病）的女性肝脏的影响。

Effect of oral 17-beta-oestradiol on the liver in women with intrahepatic cholestasis (hepatosis) during previous pregnancy.

作者信息

Jeppsson S, Rannevik G

出版信息

Br J Obstet Gynaecol. 1976 Jul;83(7):567-71. doi: 10.1111/j.1471-0528.1976.tb00887.x.

DOI:10.1111/j.1471-0528.1976.tb00887.x

Abstract

The effects of 17-beta-oestradiol in 14 women who had had intrahepatic cholestasis of pregnancy (hepatosis) were studied. This natural oestrogen was given orally in a daily dose of 5 mg for two 20-day periods with a 7-day interval between courses. The bromsulphthalein (BSP) retention rose during the treatment, but only occasionally to levels above the upper limit of normal. Other conventional liver function tests did not usually become abnormal. In a previous investigation in the same type of patients, we studied the effects of mestranol (a synthetic 17-alkylated oestrogen) in a daily dose of 0.1 mg with the same dose-schedule as the present investigation and 17-beta-oestradiol appeared to impair liver function less than mestranol. It might thus be safer to use 17-beta-oestradiol as a therapeutic agent.

摘要

研究了17-β-雌二醇对14名曾患妊娠肝内胆汁淤积症（肝病）妇女的影响。这种天然雌激素以每日5毫克的剂量口服，分两个20天疗程给药，疗程之间间隔7天。治疗期间溴磺酞钠（BSP）潴留增加，但仅偶尔升至正常上限以上。其他常规肝功能检查通常未出现异常。在之前对同一类患者的调查中，我们研究了炔雌醇（一种合成的17-烷基化雌激素）的影响，其每日剂量为0.1毫克，给药方案与本研究相同，结果显示17-β-雌二醇对肝功能的损害似乎小于炔雌醇。因此，使用17-β-雌二醇作为治疗药物可能更安全。