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[调节兔网织红细胞核糖体蛋白质合成的因素:细胞成熟过程中其浓度的变化]

[Factors regulating protein synthesis by rabbit reticulocyte ribosomes: variations in their concentrations during cell maturation].

作者信息

Mahendra M, Goswami N D, Kermel M, Koche M J

出版信息

C R Acad Hebd Seances Acad Sci D. 1975 May 26;280(20):2345-8.

PMID:807421
Abstract

An activator as well as an inhibitor of protein synthesis, were isolated from rabbit reticulocyte ribosomes. The ribosomes of the erythrocytes are inactive in protein synthesis and lacked the activator. However, when the activator moiety was added to the erythrocyte ribosomes, there was a significant increase in their capacity for protein synthesis, provided these ribosomes were freed of their inhibitor by washing beforehand with a detergent.

摘要

一种蛋白质合成激活剂以及一种抑制剂从兔网织红细胞核糖体中分离出来。红细胞的核糖体在蛋白质合成中无活性且缺乏激活剂。然而,当将激活剂部分添加到红细胞核糖体中时,只要这些核糖体预先用去污剂洗涤以去除其抑制剂,其蛋白质合成能力就会显著增加。

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