Clinical application of end-systolic pressure-volume relation.

On the basis of a mathematical formalism derived in previous studies, properties of the end-systolic pressure-volume (P-V) relation were analyzed to define indexes that can characterize a normal or failing left ventricle. Careful analysis of different areas under the P-V line can lead to new indexes that describe the performance of the left ventricle. The possibility to distinguish between normal, mildly depressed, or severely depressed left ventricles based on P-V relation is discussed. Implementation of the results for routine clinical work is examined.