Schwartz G G, Oeler T A, Uskoković M R, Bahnson R R
Department of Clinical Epidemiology and Family Medicine, University of Pittsburgh Medical Center, PA.
Anticancer Res. 1994 May-Jun;14(3A):1077-81.
1,25-Dihydroxyvitamin D [1,25(OH)2D3, calcitriol] can inhibit the proliferation of some human prostate cancer cells but its clinical use is limited by hypercalcemia. We therefore explored the bioactivity of less calcemic vitamin D analogs. We studied the effects of calcitriol and 3 synthetic analogs at concentrations of 10(-6) to 10(-12) M on the in vitro proliferation of 3 human prostate carcinoma cell lines: DU 145, PC-3, and LNCaP. Calcitriol and analogs showed significant antiproliferative activity on PC-3 and LNCaP cells. DU 145 cells were inhibited by the analogs only. We conclude that vitamin D analogs warrant further investigation as therapeutic agents in prostate cancer.
1,25 - 二羟基维生素D[1,25(OH)₂D₃，骨化三醇]可抑制某些人前列腺癌细胞的增殖，但其临床应用因高钙血症而受到限制。因此，我们探索了低钙血症维生素D类似物的生物活性。我们研究了骨化三醇和3种合成类似物在10⁻⁶至10⁻¹² M浓度下对3种人前列腺癌细胞系（DU 145、PC - 3和LNCaP）体外增殖的影响。骨化三醇和类似物对PC - 3和LNCaP细胞显示出显著的抗增殖活性。DU 145细胞仅被类似物抑制。我们得出结论，维生素D类似物作为前列腺癌治疗药物值得进一步研究。
