Asaumi J, Kawasaki S, Nishikawa K, Kuroda M, Hiraki Y
Department of Radiology, Okayama University Medical School, Japan.
Anticancer Res. 1994 May-Jun;14(3A):805-7.
We investigated the effects of amiloride and its derivative MH-12-43 on the thermosensitivity of adriamycin-resistant cells. Effects of hyperthermia at 42 degrees C were enhanced by 0.5 mM amiloride and 0.05 mM MH-12-43, which resulted in no decrease in survival rate by the treatment at 37 degrees C for 120 min. Therefore, the combination of hyperthermia and amiloride derivatives was effective in the adriamycin-resistant cells as well as wild type cells. Further, since the survival rates by the treatment with 0.05 mM MH-12-43 were markedly lower than those with 0.5 mM amiloride from hyperthermia at 42 degrees C, MH-12-43 might be more effective than amiloride.
我们研究了阿米洛利及其衍生物MH-12-43对阿霉素耐药细胞热敏感性的影响。42℃热疗的效果通过0.5 mM阿米洛利和0.05 mM MH-12-43得到增强，这导致在37℃处理120分钟后存活率没有降低。因此，热疗与阿米洛利衍生物的联合应用对阿霉素耐药细胞和野生型细胞均有效。此外，由于在42℃热疗时，0.05 mM MH-12-43处理后的存活率明显低于0.5 mM阿米洛利处理后的存活率，MH-12-43可能比阿米洛利更有效。
