Medioni D, Pages A, Sarda P
Laboratoire d'Anatomie et de Cytologie Pathologiques, Hôpital, Gui-de-Chauliac, Montpellier.
Arch Anat Cytol Pathol. 1994;42(1):29-34.
Two cases of cardiac rhabdomyoma have recently been observed in foetuses. The cardiac and muscular nature of the cells was confirmed by immunohistochemistry using monoclonal antibodies. A review of the literature shows that cardiac rhabdomyomas are usually considered to be hamartomas which are composed of primitive myocardial cells. Their spontaneous regression is often observed and apoptosis has been proposed as a possible mechanism of such a phenomenon. We propose that cardiac rhabdomyomas should be better considered as developmental vestiges rather than as true hamartomas. These vestigial structures would result either from a defect in differentiation, or from a defect in regression of primitive myocardial cells.
最近在胎儿中观察到两例心脏横纹肌瘤。使用单克隆抗体通过免疫组织化学证实了细胞的心脏和肌肉性质。文献综述表明，心脏横纹肌瘤通常被认为是由原始心肌细胞组成的错构瘤。经常观察到它们的自发消退，并且有人提出细胞凋亡是这种现象的一种可能机制。我们建议，心脏横纹肌瘤应更好地被视为发育遗迹，而不是真正的错构瘤。这些残留结构可能是由于分化缺陷或原始心肌细胞消退缺陷所致。
