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药物性运动障碍:是现实还是神话?

Drug induced dyskinesia: reality or myth?

作者信息

Turek I S

出版信息

Dis Nerv Syst. 1975 Jul;36(7):397-9.

PMID:807464
Abstract

Psychotropic medication employed in the long-term therapy of mental patients is etiologically linked to oral dyskinesia. Although the term "oral dyskinesia" is used interchangeably with "drug-induced dyskinesia" this author doesn't find sufficient scientific evidence from published studies to implicate the psychotropic drugs solely responsible for "oral dyskinesia." All the previous studies attempting to link drugs etiologically with oral dyskinesia suffered from lack of adequate information and methodological difficulties inherent in the question involved. In this paper the concept of "drug-induced dyskinesia" is rejected despite the fact that dyskinesia, from whatever etiology, is observed in certain individuals with high anxiety level and its dependent variable, the history of a psychotropic drug usage.

摘要

用于精神病人长期治疗的精神药物在病因上与口腔运动障碍有关。尽管“口腔运动障碍”一词与“药物性运动障碍”可互换使用,但作者并未从已发表的研究中找到充分的科学证据表明精神药物是导致“口腔运动障碍”的唯一原因。以往所有试图将药物与口腔运动障碍建立病因联系的研究都存在信息不足以及所涉问题固有的方法学困难。在本文中,“药物性运动障碍”这一概念被摒弃,尽管事实上,无论病因如何,在某些焦虑水平较高且有精神药物使用史这一相关变量的个体中会观察到运动障碍。

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