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Exploring DNA minor groove interactions through a probe conjugate in major groove: fluorescence studies on netropsin complexation with dU-5-aminodansyl-DNA.

作者信息

Barawkar D A, Ganesh K N

机构信息

Division of Organic Chemistry, National Chemical Laboratory, Pune, India.

出版信息

Biochem Biophys Res Commun. 1994 Aug 30;203(1):53-8. doi: 10.1006/bbrc.1994.2147.

DOI:10.1006/bbrc.1994.2147
PMID:8074699
Abstract

The binding of netropsin to 5-Aminodansyl-dU-DNA (2-5) in minor groove is shown to correlate with fluorescence changes of dansyl fluorophore located in major groove. This enables a study of a minor groove binding event through crosstalk with conjugated probe in major groove. The dielectric constant of major groove estimated from fluorescence properties of (2-6) is about 55D in contrast to the literature reported minor groove dielectric constant of 20D in the poly[d(AT)]-poly[d(AT)] duplex.

摘要

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