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用于人类诊断和治疗的变应原提取物标准化的必要性。

The need for standardization of allergenic extracts utilized in humans for diagnosis and therapy.

作者信息

Desbordes J

出版信息

Dev Biol Stand. 1975;29:267-75.

PMID:807492
Abstract

It seems clear that the results of allergenic immunotherapy depend on the value of the allergens available. In our opinion the following points should be discussed and clarified : the choice of allergenic substances, potency units, therapeutic dilutions, delayed action allergens, active antibodies, standardization of allergens of well-determined biological species (plants, mould, microscopic fungi, microbial germs, house dust, pollens, parasites), standardization of adjuvants, standardization of allergen dispensation, solvents used for dilutions, solutions used for dilutions, preservatives, etc. A great deal of work is involved and should be undertaken without delay on an international scale.

摘要

显然,变应原免疫疗法的效果取决于所用变应原的质量。我们认为,应讨论并阐明以下几点:变应原物质的选择、效价单位、治疗稀释度、迟发型变应原、活性抗体、明确生物物种(植物、霉菌、微真菌、微生物、屋尘、花粉、寄生虫)变应原的标准化、佐剂的标准化、变应原给药的标准化、稀释用溶剂、稀释用溶液、防腐剂等。这涉及大量工作,应立即在国际范围内开展。

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