Manzullo E F
Section of General Internal Medicine, University of Texas M.D. Anderson Cancer Center, Houston.
Oncology (Williston Park). 1994 Jun;8(6):115-20; discussion 120, 123.
Septic shock is currently the most common cause of death in noncoronary intensive care units in the United States. The pathogenesis of sepsis involves a variety of cytokine and noncytokine mediators, which, when activated, can result in a self-perpetuating cascade. This systemic response to infection is a frequent cause of multi-organ system failure and death. Treatment has traditionally focused on antibiotic therapy, but this has not significantly changed patient outcomes. Steroids have been shown to be of little or no value and studies evaluating monoclonal antibodies that target the mediators of the sepsis cascade have not produced promising results.
在美国，感染性休克目前是非冠状动脉重症监护病房中最常见的死亡原因。脓毒症的发病机制涉及多种细胞因子和非细胞因子介质，这些介质一旦被激活，可导致一种自我持续的级联反应。这种对感染的全身反应是多器官系统衰竭和死亡的常见原因。传统上，治疗主要集中在抗生素治疗上，但这并没有显著改变患者的预后。已证明类固醇几乎没有价值或毫无价值，评估针对脓毒症级联反应介质的单克隆抗体的研究也未取得有前景的结果。
