Avila J, Domínguez J, Díaz-Nido J
Centro de Biologia Molecular Severo Ochoa, Universidad Autónoma, Madrid, Spain.
Int J Dev Biol. 1994 Mar;38(1):13-25.
Neuronal morphogenesis is driven by cytoskeletal changes in which microtubules play a leading role. A very heterogeneous group of microtubule-associated proteins (MAPs) seems to control the dynamics and contribute to the organization of the microtubule cytoskeleton. Of great importance in this regard is the developmental regulation of the expression of certain MAPs in specific neuronal compartments. Furthermore, MAP functionality is also modulated by phosphorylation and dephosphorylation events. A correlation between the expression and/or phosphorylation of distinct MAPs and definite stages of neuronal development may be established. A putative role in synaptic plasticity for MAP modifications similar to those occurring during development can be anticipated. Interestingly, gross alterations in microtubule-associated proteins are found in several neuropathologies including Alzheimer's disease. In this review we focus on recent advances in the understanding of the molecular properties of major neuronal MAPs which may be relevant to these issues.
神经元形态发生由细胞骨架变化驱动，其中微管发挥主导作用。一组非常异质的微管相关蛋白（MAPs）似乎控制着微管的动力学，并有助于微管细胞骨架的组织。在这方面，特定神经元区室中某些MAPs表达的发育调控非常重要。此外，MAP的功能也受到磷酸化和去磷酸化事件的调节。可以建立不同MAPs的表达和/或磷酸化与神经元发育的特定阶段之间的相关性。可以预期，与发育过程中发生的那些类似的MAP修饰在突触可塑性中具有假定作用。有趣的是，在包括阿尔茨海默病在内的几种神经病理学中发现了微管相关蛋白的明显改变。在本综述中，我们关注对可能与这些问题相关的主要神经元MAPs分子特性理解的最新进展。
