Fijen C A, Kuijper E J, Tjia H G, Daha M R, Dankert J
Department of Medical Microbiology, University of Amsterdam, The Netherlands.
Clin Infect Dis. 1994 May;18(5):780-4. doi: 10.1093/clinids/18.5.780.
Nongroupable meningococci or bacteria related to the genus Neisseria rarely cause meningitis. Complement deficiency has been identified as a major predisposing factor for meningococcal disease. To assess whether patients with meningitis due to such strains have a complement deficiency, we studied 12 persons. Six patients had meningitis due to nongroupable strains of meningococci, and six patients had meningitis due to Moraxella species or Acinetobacter species. Inherited complement component C7 or C8 deficiency was found in two persons who had had meningitis due to nongroupable meningococci, and one C8-deficient person had had meningitis caused by Moraxella osloensis. Hypocomplementemia resulting from CSF drain-associated shunt nephritis was found in one person with meningitis due to Moraxella nonliquefaciens and in one person with meningitis due to Acinetobacter lwoffi. This rather high frequency of inherited or acquired complement deficiencies among patients with meningitis due to nongroupable meningococci, Moraxella species, and Acinetobacter species justifies the recommendation that such patients must be studied for complement deficiency.
不可分组的脑膜炎球菌或与奈瑟菌属相关的细菌很少引起脑膜炎。补体缺乏已被确定为脑膜炎球菌病的主要易感因素。为了评估因这类菌株导致脑膜炎的患者是否存在补体缺乏，我们研究了12名患者。6例患者因不可分组的脑膜炎球菌菌株导致脑膜炎，6例患者因莫拉菌属或不动杆菌属导致脑膜炎。在2例因不可分组的脑膜炎球菌导致脑膜炎的患者中发现了遗传性补体成分C7或C8缺乏，1例C8缺乏的患者患有奥斯陆莫拉菌引起的脑膜炎。在1例因非液化莫拉菌导致脑膜炎的患者和1例因洛菲不动杆菌导致脑膜炎的患者中发现了脑脊液引流相关分流性肾炎导致的低补体血症。在因不可分组的脑膜炎球菌、莫拉菌属和不动杆菌属导致脑膜炎的患者中，遗传性或获得性补体缺乏的频率相当高，这证明了对这类患者进行补体缺乏研究的建议是合理的。
