Zhang S X, Seguchi H
Department of Anatomy and Cell Biology, Kochi Medical School, Japan.
Histol Histopathol. 1994 Apr;9(2):315-23.
The fate of the luminal asymmetric unit membrane (AUM) of the superficial cell of the transitional epithelium of the rat urinary bladder was electron microscopically and cytochemically investigated using exogenously administered horseradish peroxidase (HRP) as tracer. HRP-positive discoidal vesicles were formed by the folding of the AUM of the luminal surface plasma membrane. With the passage of time, these vesicles changed their shapes and were finally transformed into lysosomes by the following possible routes: 1) by becoming multivesicular bodies (MVBs); 2) by directly fusing with lysosomes; and 3) by becoming autophagic vacuoles. Another possibility would be reutilization.
以外源给予的辣根过氧化物酶（HRP）作为示踪剂，通过电子显微镜和细胞化学方法研究了大鼠膀胱移行上皮表层细胞腔面膜不对称单位膜（AUM）的命运。HRP阳性的盘状小泡由腔面膜表面质膜的AUM折叠形成。随着时间的推移，这些小泡改变形状，最终通过以下可能途径转化为溶酶体：1）变成多泡体（MVB）；2）直接与溶酶体融合；3）变成自噬泡。另一种可能性是再利用。
