葡萄糖强烈刺激艾氏腹水癌细胞中rRNA的合成速率。
Glucose strongly stimulates rate of the rRNA synthesis in Ehrlich ascites carcinoma cells.
作者信息
Buzhurina I M, Chernaya N G, Panov M A
机构信息
Laboratory of Cell Physiology, A.N. Belozersky Institute of Physical and Chemical Biology, Moscow State University, Russia.
出版信息
Cell Biol Int. 1994 Jun;18(6):673-5. doi: 10.1006/cbir.1994.1095.
PMID:8075629
Abstract
A change in glucose concentration in an Ehrlich ascites carcinoma cell suspension from 0.1 mM to 20 mM causes a more than 50-fold stimulation of the rate of ribosomal RNA synthesis. Such an effect occurs without any dramatic effect on the rate of protein synthesis in cells. This process parallels a decrease in intracellular pH which may be a reason of Na+/H(+)-antiport activation.
摘要
艾氏腹水癌细胞悬液中葡萄糖浓度从0.1 mM变为20 mM会使核糖体RNA合成速率受到超过50倍的刺激。这种效应在对细胞内蛋白质合成速率没有任何显著影响的情况下发生。这一过程与细胞内pH值的降低同时出现，而细胞内pH值降低可能是钠/氢反向转运体激活的原因。
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