Lebherz H G
J Biol Chem. 1975 Aug 10;250(15):5967-75.
The intraccellular proteins of animal cells are continuously turning over; therefore, the concentration of a given protein is regulated both at the level of protein synthesis and at the level of protein degradation. Studies on the relative rates of turnover of isoenzymes, such as those of aldolase and lactate dehydrogenase, may help to clarify the mechanisms involved in protein turnover. The isoenzymes and subunit types are very similar proteins, and are located within the same intracellular compartments; yet, the concentrations of these proteins are independently regulated. The present paper describes the roles of synthesis and degradation in regulating aldolase isoenzyme concentrations in avian brain...
动物细胞内的蛋白质不断更新；因此，特定蛋白质的浓度在蛋白质合成水平和蛋白质降解水平上均受到调控。对同工酶（如醛缩酶和乳酸脱氢酶）相对更新速率的研究，可能有助于阐明蛋白质更新所涉及的机制。这些同工酶和亚基类型是非常相似的蛋白质，位于相同的细胞内区室中；然而，这些蛋白质的浓度是独立调控的。本文描述了合成和降解在调节禽脑醛缩酶同工酶浓度中的作用……
