Howard J B, Fausch M D
J Biol Chem. 1975 Aug 10;250(15):6178-80.
The amino acid sequence of a 31-residue peptide from bovine prothrombin has been determined. This peptide has been shown to contain the vitamin K-dependent modification required for Ca2+ binding (Nelsestuen, G. L., and Suttie, J. W. (1973) Proc. Natl. Acad. Sci. U. S. A. 70, 3366-3370) and the modified amino acid, gamma-carboxyglutamic acid (Nelsestuen, G. L., Zytkovicz, T., and Howard, J. B. (1974) J. Biol. Chem. 249, 6347-6350). The peptide was shown to correspond to residues 12 to 42 of prothrombin.
已确定来自牛凝血酶原的一段31个残基的肽的氨基酸序列。该肽已被证明含有Ca2+结合所需的维生素K依赖性修饰（内尔塞斯图恩，G.L.，和萨蒂，J.W.（1973年）《美国国家科学院院刊》70，3366 - 3370）以及修饰的氨基酸γ-羧基谷氨酸（内尔塞斯图恩，G.L.，齐特科维茨，T.，和霍华德，J.B.（1974年）《生物化学杂志》249，6347 - 6350）。该肽被证明对应于凝血酶原的第12至42位残基。
