大鼠颈上神经节中ATP和UTP不同受体的脱敏研究证据。
Evidence from desensitization studies for distinct receptors for ATP and UTP on the rat superior cervical ganglion.
作者信息
Connolly G P
机构信息
Department of Physiology, University College London.
出版信息
Br J Pharmacol. 1994 Jun;112(2):357-9. doi: 10.1111/j.1476-5381.1994.tb13079.x.
Abstract
Prolonged contact of the rat superior cervical ganglia (SCG) with the purine alpha,beta-methylene-ATP (alpha,beta-Me-ATP) selectively depressed responses to ATP and alpha,beta-Me-ATP but not responses to uridine 5'-triphosphate (UTP), potassium or adenosine. Prolonged contact with the pyrimidine UTP selectively depressed responses to UTP but not responses evoked by alpha,beta-Me-ATP, potassium or adenosine. These results are consistent with the presence of P2-purinoceptors and pyrimidinoceptors on the rat SCG and the hypothesis that pyrimidinoceptors exist within the nervous system.
摘要
大鼠颈上神经节（SCG）与嘌呤α,β-亚甲基-ATP（α,β-Me-ATP）长时间接触，可选择性地抑制对ATP和α,β-Me-ATP的反应，但不影响对尿苷5'-三磷酸（UTP）、钾或腺苷的反应。与嘧啶UTP长时间接触可选择性地抑制对UTP的反应，但不影响由α,β-Me-ATP、钾或腺苷引发的反应。这些结果与大鼠SCG上存在P2-嘌呤受体和嘧啶受体以及神经系统中存在嘧啶受体的假说相一致。
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本文引用的文献
1
Action of purine and pyrimidine nucleotides on the rat superior cervical ganglion.嘌呤和嘧啶核苷酸对大鼠颈上神经节的作用。
Br J Pharmacol. 1993 Dec;110(4):1297-304. doi: 10.1111/j.1476-5381.1993.tb13959.x.
2
Actions of extracellular UTP and ATP in perfused rat liver. A comparative study.细胞外三磷酸尿苷（UTP）和三磷酸腺苷（ATP）在灌注大鼠肝脏中的作用。一项比较研究。
Eur J Biochem. 1987 Aug 17;167(1):65-71. doi: 10.1111/j.1432-1033.1987.tb13304.x.
3
Evidence for a vasoconstriction-mediating receptor for UTP, distinct from the P2 purinoceptor, in rabbit ear artery.在兔耳动脉中，存在一种与P2嘌呤受体不同的、介导UTP血管收缩作用的受体的证据。
Naunyn Schmiedebergs Arch Pharmacol. 1987 Nov;336(5):556-60. doi: 10.1007/BF00169313.
4
Is there a basis for distinguishing two types of P2-purinoceptor?是否有依据区分两种类型的P2嘌呤受体？
Gen Pharmacol. 1985;16(5):433-40. doi: 10.1016/0306-3623(85)90001-1.
5
Involvement of pyrimidinoceptors in the regulation of cell functions by uridine and by uracil nucleotides.嘧啶受体参与尿苷和尿嘧啶核苷酸对细胞功能的调节。
Trends Pharmacol Sci. 1989 Sep;10(9):365-9. doi: 10.1016/0165-6147(89)90009-6.
6
Constriction of the smooth muscle of rat tail and femoral arteries and dog saphenous vein is induced by uridine triphosphate via 'pyrimidinoceptors', and by adenosine triphosphate via P2x purinoceptors.
Blood Vessels. 1990;27(6):352-64. doi: 10.1159/000158829.
7
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Biochem J. 1990 Dec 1;272(2):469-72. doi: 10.1042/bj2720469.
8
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Trends Pharmacol Sci. 1991 Apr;12(4):137-41. doi: 10.1016/0165-6147(91)90530-6.
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