大鼠颈上神经节中ATP和UTP不同受体的脱敏研究证据。
Evidence from desensitization studies for distinct receptors for ATP and UTP on the rat superior cervical ganglion.
作者信息
Connolly G P
机构信息
Department of Physiology, University College London.
出版信息
Br J Pharmacol. 1994 Jun;112(2):357-9. doi: 10.1111/j.1476-5381.1994.tb13079.x.
Prolonged contact of the rat superior cervical ganglia (SCG) with the purine alpha,beta-methylene-ATP (alpha,beta-Me-ATP) selectively depressed responses to ATP and alpha,beta-Me-ATP but not responses to uridine 5'-triphosphate (UTP), potassium or adenosine. Prolonged contact with the pyrimidine UTP selectively depressed responses to UTP but not responses evoked by alpha,beta-Me-ATP, potassium or adenosine. These results are consistent with the presence of P2-purinoceptors and pyrimidinoceptors on the rat SCG and the hypothesis that pyrimidinoceptors exist within the nervous system.
大鼠颈上神经节（SCG）与嘌呤α,β-亚甲基-ATP（α,β-Me-ATP）长时间接触，可选择性地抑制对ATP和α,β-Me-ATP的反应，但不影响对尿苷5'-三磷酸（UTP）、钾或腺苷的反应。与嘧啶UTP长时间接触可选择性地抑制对UTP的反应，但不影响由α,β-Me-ATP、钾或腺苷引发的反应。这些结果与大鼠SCG上存在P2-嘌呤受体和嘧啶受体以及神经系统中存在嘧啶受体的假说相一致。
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