曲弗洛辛，一种新型的近端小管钠-碳酸氢根同向转运体抑制剂。
Triflocin, a novel inhibitor for the Na-HCO3 symport in the proximal tubule.
作者信息
Belachgar F, Hulin P, Anagnostopoulos T, Planelles G
机构信息
INSERM U. 323, CHU Necker Enfants-Malades, Paris, France.
出版信息
Br J Pharmacol. 1994 Jun;112(2):465-70. doi: 10.1111/j.1476-5381.1994.tb13096.x.
Abstract
- Triflocin, applied at millimolar concentration hyperpolarizes the basolateral membrane of Necturus proximal convoluted tubular cells, in vivo. 2. Barium, 2.5 x 10(-3) M, ouabain, 10(-3) M, or amiloride 10(-4) M, fail to prevent this hyperpolarization. 3. Triflocin has no effect on the intracellular chloride activity. 4. In physiological acid base conditions, Triflocin increases intracellular pH. 5. Upon an acute isohydric hypercapnia, Triflocin depolarizes the basolateral membrane potential. 6. It is concluded that, Triflocin inhibits the basolateral electrogenic Na-(HCO3)n > 1 cotransport in proximal tubules.
摘要
- 在体内，以毫摩尔浓度应用的曲弗罗辛可使美西螈近端曲管细胞的基底外侧膜超极化。2. 2.5×10⁻³M的钡、10⁻³M的哇巴因或10⁻⁴M的氨氯吡咪均不能阻止这种超极化。3. 曲弗罗辛对细胞内氯离子活性无影响。4. 在生理酸碱条件下，曲弗罗辛可提高细胞内pH值。5. 在急性等渗性高碳酸血症时，曲弗罗辛使基底外侧膜电位去极化。6. 得出的结论是，曲弗罗辛抑制近端小管基底外侧的电生性Na⁺-(HCO₃)ₙ（n＞1）协同转运。
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