Takeichi M, Watabe M, Shibamoto S, Ito F, Oda H, Uemura T, Shimamura K
Department of Biophysics, Faculty of Science, Kyoto University, Japan.
C R Acad Sci III. 1993 Sep;316(9):813-21.
Cadherin cell-cell adhesion molecules are associated with cytoskeletal proteins, including alpha and beta catenin, and plakoglobin. This cadherin-catenin complex plays an indispensable role in construction of ordered multicellular structures such as polarized epithelium. alpha-catenin is crucial for the cell binding function of cadherins; without it, cells cannot use the cadherin adhesion system for their adhesion. beta-catenin and plakoglobin possibly play more regulatory roles, as it was shown that their tyrosine phosphorylation correlated with modified cadherin activities. The expression of some cadherin-associated proteins is controlled by the wingless/Wnt-1 signal in embryos. These regulatory mechanisms of cadherin function and expression may be involved in dynamic control of cell-cell contacts during morphogenesis, and even in certain processes of cell growth and differentiation.
钙黏蛋白细胞间黏附分子与细胞骨架蛋白相关联，包括α - 连环蛋白、β - 连环蛋白和桥粒斑珠蛋白。这种钙黏蛋白 - 连环蛋白复合物在构建有序的多细胞结构（如极化上皮）中起着不可或缺的作用。α - 连环蛋白对于钙黏蛋白的细胞结合功能至关重要；没有它，细胞就无法利用钙黏蛋白黏附系统进行黏附。β - 连环蛋白和桥粒斑珠蛋白可能发挥更多的调节作用，因为研究表明它们的酪氨酸磷酸化与钙黏蛋白活性的改变相关。在胚胎中，一些钙黏蛋白相关蛋白的表达受无翅型/翼状螺旋转录因子1（Wingless/Wnt-1）信号的控制。这些钙黏蛋白功能和表达的调节机制可能参与形态发生过程中细胞间接触的动态控制，甚至参与细胞生长和分化的某些过程。
