Sayrak H, Doğan B, Harmanyeri Y, Oztek I, Cingil H
Department of Pathology, GATA Teaching Hospital, Haydarpaşa, Istanbul, Turkey.
Cancer Lett. 1994 Sep 15;84(2):173-6. doi: 10.1016/0304-3835(94)90372-7.
We present the case of a 27-year-old Caucasian woman who suffered from Langerhans cell histiocytosis with axillary and scalp involvement. She also developed diabetes insipidus after 2 years of skin lesions. Topical nitrogen mustard therapy was performed for the skin lesions, but we had to stop this therapy because of severe local irritation and systemic urticaria. Afterwards, we administered etoposide systemically, but no improvement appeared in 6 weeks. Finally we used methotrexate for 3 months and the result was very good at the end of the first month.
我们报告了一例27岁的白种女性，患有朗格汉斯细胞组织细胞增多症，累及腋窝和头皮。在出现皮肤病变2年后，她还患上了尿崩症。对皮肤病变进行了局部氮芥治疗，但由于严重的局部刺激和全身性荨麻疹，我们不得不停止该治疗。之后，我们全身给予依托泊苷，但6周内未见改善。最后我们使用甲氨蝶呤治疗3个月，在第一个月末效果非常好。
