Sala D T
ENT Department, Piove di Sacco, Padova, Italy.
Ear Nose Throat J. 1994 Jun;73(6):412-4.
Recent studies have demonstrated that aural cholesteatoma features intense DNA turnover in the germinative layer of the matrix and an immune response in the wall of the cyst, which trigger a chain reaction. 5-Fluorouracil, an antimetabolitic agent that is also effective topically, was applied to the cyst wall in the initial cholesteatoma, in relapsing cholesteatoma (even transtympanically) and in large exudative cavities resulting from attico-antrectomy: in all cases, it inhibited the formation of keratin and reduced the mucous hypersecretion. These results have persisted even after 12 months of suspending treatment.
最近的研究表明，耳胆脂瘤在基质生发层有强烈的DNA周转，在囊肿壁有免疫反应，这引发了连锁反应。5-氟尿嘧啶是一种局部也有效的抗代谢药物，被应用于初发性胆脂瘤、复发性胆脂瘤（甚至经鼓室给药）以及鼓窦天盖切除术导致的大渗出腔的囊肿壁：在所有病例中，它抑制了角蛋白的形成并减少了黏液分泌过多。即使在停止治疗12个月后，这些结果仍然存在。
