哇巴因对蟾蜍膀胱钠转运的作用：钠进入的两条途径的证据
Action of ouabain on sodium transport in toad urinary bladder, Evidence for two pathways for sodium entry.
作者信息
Finn A L
出版信息
J Gen Physiol. 1975 Apr;65(4):503-14. doi: 10.1085/jgp.65.4.503.
Abstract
The cardiac glycoside ouabain inhibits transepithelial sodium transport in the toad urinary bladder. It is shown that this drug reduces the rate coefficient for sodium exit at the serosal pump site. In addition, ouabain inhibits entry across the mucosal border whenever the electrochemical potential gradient for sodium is made less favorable. The data are interpreted as indicating the existence of two separate pathways for sodium entry, one of which is ouabain inhibitable.
摘要
强心苷哇巴因可抑制蟾蜍膀胱的跨上皮钠转运。结果表明，这种药物降低了钠在浆膜泵部位的排出速率系数。此外，只要钠的电化学势梯度变得不利，哇巴因就会抑制钠跨黏膜边界的进入。这些数据被解释为表明存在两种独立的钠进入途径，其中一种可被哇巴因抑制。
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本文引用的文献
1
INTRACELLULAR ELECTRICAL POTENTIALS IN FROG SKIN.
J Gen Physiol. 1965 Mar;48(4):543-57. doi: 10.1085/jgp.48.4.543.
2
The electrical characteristics of active sodium transport in the toad bladder.
J Gen Physiol. 1963 Jan;46(3):491-503. doi: 10.1085/jgp.46.3.491.
3
The routine fitting of kinetic data to models: a mathematical formalism for digital computers.
Biophys J. 1962 May;2(3):275-87. doi: 10.1016/s0006-3495(62)86855-6.
4
Active sodium transport by the isolated toad bladder.
J Gen Physiol. 1958 Mar 20;41(4):657-68. doi: 10.1085/jgp.41.4.657.
5
Relation between toad bladder potassium content and permeability response to vasopressin.
Am J Physiol. 1966 Jun;210(6):1279-84. doi: 10.1152/ajplegacy.1966.210.6.1279.
6
Action of ouabain on bioelectric properties and ion content in toad urinary bladder.
Am J Physiol. 1968 Jul;215(1):183-9. doi: 10.1152/ajplegacy.1968.215.1.183.
7
Effect of changes in transepithelial transport on the uptake of sodium across the outer surface of the frog skin.
J Gen Physiol. 1971 Aug;58(2):131-44. doi: 10.1085/jgp.58.2.131.
8
The kinetics of sodium transport in the toad bladder. II. Dual effects of vasopressin.
J Gen Physiol. 1971 Mar;57(3):349-62. doi: 10.1085/jgp.57.3.349.
9
The kinetics of sodium transport in the toad bladder. I. Determination of the transport pool.
J Gen Physiol. 1971 Mar;57(3):326-48. doi: 10.1085/jgp.57.3.326.
10
Nonpolarized frog bladder preparation. The effects of oxytocin.
Pflugers Arch. 1970;318(4):294-304. doi: 10.1007/BF00586969.
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