网格蛋白相关衔接蛋白的两种大鼠同源物。
Two rat homologs of clathrin-associated adaptor proteins.
作者信息
Pevsner J, Volknandt W, Wong B R, Scheller R H
机构信息
Department of Molecular and Cellular Physiology, Howard Hughes Medical Institute, Beckman Center, Stanford University Medical School, CA 94305.
出版信息
Gene. 1994 Sep 2;146(2):279-83. doi: 10.1016/0378-1119(94)90306-9.
A cDNA clone predicted to encode a 46,757-Da protein was isolated from a library derived from the electric lobe of the ray Discopyge ommata. Two rat homologs, p47A and p47B, were subsequently isolated. These three proteins share approx. 80% amino acid (aa) identity to each other and have 27-30% aa identity to rat AP50 and mouse AP47, the medium-chain subunits of adaptor complexes associated with clathrin-coated vesicles. These complexes are involved in receptor-mediated pathways of intracellular transport. Rat p47A mRNA is expressed in all tissues examined, including brain, heart, kidney, liver, lung, muscle and spinal cord. Rat p47B mRNA is detected exclusively in brain and spinal cord, and may participate in nervous system-specific functions such as biogenesis or recycling of synaptic vesicles.
从电鳐（Discopyge ommata）电叶来源的文库中分离出一个预测编码46,757道尔顿蛋白质的cDNA克隆。随后分离出两个大鼠同源物p47A和p47B。这三种蛋白质彼此之间的氨基酸（aa）同一性约为80%，与大鼠AP50和小鼠AP47（网格蛋白包被小泡相关衔接复合体的中链亚基）的氨基酸同一性为27%-30%。这些复合体参与细胞内运输的受体介导途径。大鼠p47A mRNA在所有检测的组织中均有表达，包括脑、心脏、肾脏、肝脏、肺、肌肉和脊髓。大鼠p47B mRNA仅在脑和脊髓中检测到，可能参与神经系统特异性功能，如突触小泡的生物发生或再循环。
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