Catania P N, King J C
J Pharm Sci. 1975 Mar;64(3):457-8. doi: 10.1002/jps.2600640324.
The results of an in vivo evaluation of silver sulfadiazine dry foam are described. Using burned guinea pigs infected with Pseudomonas aeruginosa, silver sulfadiazine was applied every 12hr as the dry foam or ointment. After 72 hr of therapy with the medicated dry foam, only one of the 15 burns remained infected while seven of the 15 burns remained positive for Pseudomonas after treatment with the corresponding medicated ointment (p less than 0.05 greater than 0.01). It is suggested that the medicated dry foam provided significantly greater activity in treating a supraeschar burn wound infection of recent onset. In addition, a modified crossover study demonstrated that both the medicated dry foam and ointment are less effective in treating subeschar burn wound infections.
本文描述了磺胺嘧啶银干泡沫剂的体内评估结果。使用感染铜绿假单胞菌的烧伤豚鼠，每12小时分别应用磺胺嘧啶银干泡沫剂或软膏。用药干泡沫剂治疗72小时后，15处烧伤中仅有1处仍有感染，而使用相应药膏治疗后，15处烧伤中有7处铜绿假单胞菌检测仍呈阳性（P＜0.05＞0.01）。提示用药干泡沫剂在治疗近期发生的焦痂上烧伤创面感染方面活性显著更高。此外，一项改良交叉研究表明，用药干泡沫剂和软膏在治疗焦痂下烧伤创面感染方面效果均较差。
