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2-Phenethylimidazole derivatives. Synthesis and antimycotic properties.

作者信息

Godefroi E F, Geenen J J, van Klingeren B, van Wijngaarden L J

出版信息

J Med Chem. 1975 May;18(5):530-3. doi: 10.1021/jm00239a022.

Abstract

Compounds of type (X = O, NH; Ar and Ar' = phenyl of substituted phenyl; ten examples) were prepared and assayed against miconazole (II,X = O; Ar = Ar' =2,4-Cl2C6H3) as potential antimycotic agents. Optimal activity was noted for I(X = O; Ar = Ar' = 2,4-Cl2C6H3), the direct analog of miconazole. It is about one-tenth as active.

摘要

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