Salvaggio J E
Tulane University Medical Center, New Orleans, LA 70112.
J Allergy Clin Immunol. 1994 Aug;94(2 Pt 2):304-9.
This brief discussion of inhaled particles, their manner of deposition and clearance, and their association with many human disease has been designed to remind us of the importance of particulate agents as sensitizers, via their allergen content, as causative agents of lung inflammation via their immunotoxic properties, as inducers of inflammatory alveolitis based on their content of antigens and adjuvant-like material, and as infectious agents. All these properties can play a part in a wide variety of allergic parenchymal, infectious, and industrial lung diseases and in building-related illnesses.
对吸入颗粒物、其沉积和清除方式以及它们与多种人类疾病的关联的简要讨论，旨在提醒我们颗粒剂作为致敏剂（通过其过敏原含量）、作为肺部炎症的致病剂（通过其免疫毒性特性）、作为基于其抗原和佐剂样物质含量的炎症性肺泡炎诱导剂以及作为传染因子的重要性。所有这些特性都可能在多种过敏性实质性、感染性和职业性肺病以及与建筑相关的疾病中起作用。
